Topical drug delivery has gained increasing attention as a non-invasive, patient-friendly, and targeted approach for managing dermatological conditions. Semisolid formulations such as creams, gels, and ointments remain the most common vehicles, offering ease of use and localized therapeutic action. Yet, the skin’s outermost barrier, the Stratum Corneum (SC), poses a major challenge by significantly limiting drug penetration, often restricting treatment effectiveness.

To address this challenge, advanced carriers such as liposomes have emerged as innovative solutions. With their phospholipid bilayer structure, liposomes not only mimic the natural composition of skin layers but also encapsulate both hydrophilic and lipophilic drugs, enhance permeation, and provide controlled release at targeted sites. When incorporated into semisolid formulations, these vesicular systems offer a synergistic advantage by improving drug retention, optimizing dermatopharmacokinetics, and minimizing systemic exposure. This white paper delves into the design, development, and therapeutic potential of such hybrid systems, highlighting their promise in shaping the future of topical dermatology.

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